Prednimustine therapy for advanced prostatic cancer.

R Catane; J H Kaufman; S Madajewicz; A Mittelman; G P Murphy

doi:10.1111/j.1464-410x.1978.tb02761.x

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Prednimustine therapy for advanced prostatic cancer.

R Catane·J H Kaufman·S Madajewicz·A Mittelman·G P Murphy

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Abstract

23 patients with advanced, hormonal-resistant, prostatic cancer were treated with daily oral prednimustine--a combination of prednisolone and chlorambucil. 8 patients (35%) subjectively responded with disappearance of skeletal pain and improvement in appetite, weight and sense of well being. 3 patients had objective evidence of tumour regression. Clinical toxicity was moderate, and only occasional myelosuppression was encountered. The ease of administration and predictable toxicity of prenimustine make it a potentially useful agent, alone or in combination, for advanced prostatic cancer.

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Adrenal Glands Aged Chemical Phenomena Chemistry Chlorambucil Drug Combinations Humans Male Middle Aged Prednisolone Prostatic Neoplasms Journal Article Research Support, U.S. Gov't, P.H.S.

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R Catane, J H Kaufman, S Madajewicz, A Mittelman, G P Murphy. 1978. Prednimustine therapy for advanced prostatic cancer.. https://doi.org/10.1111/j.1464-410x.1978.tb02761.x

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