Age-related changes in pituitary/thyroid function in chickens.

B L Carr; R B Chiasson

doi:10.1016/0016-6480(83)90238-1

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Age-related changes in pituitary/thyroid function in chickens.

B L Carr·R B Chiasson

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Abstract

Pituitary cyclic AMP-dependent protein kinase (cAMP-PK) activity ratios are not increased in response to thyrotropin-releasing hormone (TRH) in old chickens (retired White Leghorn breeders). This reduced responsiveness may be due to reduced hypothalamic function, reduced thyrotrope function, or to a reduction in TRH membrane receptors. The thyroid cAMP-PK activity ratio of old males does not respond to TRH treatment but the thyroid of old females does have an increased activity ratio ater TRH injection. Both males and females have a much higher basal cAMP-PK activity ratio than young birds. This higher basal level is thought to be due to an increased thyroid-stimulating hormone (TSH) stimulation, and the failure of old males to increase activity after TRH injections may be due to a loss of the thyroid's ability to respond to direct TRH stimulation.

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Aging Animals Chickens Cyclic AMP Female Male Pituitary Gland Protein Kinases Thyroid Gland Thyrotropin-Releasing Hormone Journal Article Research Support, Non-U.S. Gov't

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B L Carr, R B Chiasson. 1983. Age-related changes in pituitary/thyroid function in chickens.. https://doi.org/10.1016/0016-6480(83)90238-1

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