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Hypophysectomy alters both 5-hydroxytryptamine- and alpha 2-adrenoceptor-mediated behavioural changes in the rat.

D J Heal·K M O'Shaughnessy·S L Smith·D J Nutt
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Abstract

Hypophysectomy, but not sham-hypophysectomy, reduced tranylcypromine/L-tryptophan hyperactivity when compared with unoperated controls although brain 5-hydroxytryptamine concentrations were not different. Hypophysectomy also reduced quipazine locomotor activity but did not alter spontaneous locomotion. Hypophysectomy potentiated clonidine hypoactivity but did not itself produce sedation. Furthermore, noradrenaline concentrations were not altered in either hypothalamus or nucleus accumbens. This suggests that pituitary function is necessary for the normal manifestation of behaviours mediated by postsynaptic 5-hydroxytryptamine receptors and presynaptic alpha 2-adrenoceptors.

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AnimalsBehavior, AnimalClonidineHypophysectomyMaleMotor ActivityQuipazineRatsRats, Inbred StrainsReceptors, AdrenergicReceptors, Adrenergic, alphaSerotoninTryptophanJournal Article

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D J Heal, K M O'Shaughnessy, S L Smith, D J Nutt. 1983-04-22. Hypophysectomy alters both 5-hydroxytryptamine- and alpha 2-adrenoceptor-mediated behavioural changes in the rat.. https://doi.org/10.1016/0014-2999(83)90624-6

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