Changes in stem cell compartments in mice after hydroxyurea.

E Necas; P Ponka; J Neuwirt

doi:10.1111/j.1365-2184.1978.tb00880.x

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Changes in stem cell compartments in mice after hydroxyurea.

E Necas·P Ponka·J Neuwirt

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Abstract

Hydroxyurea injection kills only approximately 10% of CFUs which are in the S phase of the cell cycle. In mice given a single injection of hydroxyurea CFUs in the femur decreased only about 50% in 2--4 days after hydroxyurea, and then started to return to normal levels with an overshoot evident after the eighth day after hydroxyurea. CFUs in spleens of mice given a single injection of hydroxyurea show an evident overshoot as early as 3 days after the drug, reaching levels which are about 300% of normal. CFUs from blood disappear rapidly, but equally rapidly return to normal values followed by a significant overshoot. The radioresistance of mice increased up to 4 days after hydroxyurea.

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Animals Blood Cells Bone Marrow Cells Erythropoiesis Female Hematopoietic Stem Cells Hydroxyurea Kinetics Mice Mice, Inbred Strains Radiation-Protective Agents Spleen Journal Article

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E Necas, P Ponka, J Neuwirt. 1978. Changes in stem cell compartments in mice after hydroxyurea.. https://doi.org/10.1111/j.1365-2184.1978.tb00880.x

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