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Elevated serum angiotensin-converting enzyme in hyperthyroidism.

E Silverstein·G C Schussler·J Friedland
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Abstract

Serum angiotensin-converting enzyme was elevated in patients with hyperthyroidism (72 +/- 31 nmol/minute/ml, n = 12, p less than 0.001) but not in patients with hypothyroidism (38 +/- 3, n = 3) or thyroiditis (26, n = 1), and was positively correlated in 23 patients with serum thyroxine concentration (r = 0.60, p less than 0.01) and triiodothyronine resin uptake (r = 0.56, p less than 0.01). Triiodothyronine failed to enhance the synthesis of angiotensin-converting enzyme in rabbit alveolar macrophages or in human monocytes in culture, suggesting that the increased serum enzyme is a consequence of an effect other than increased angiotensin-converting enzyme synthesis. Hyperthyroidism should be considered in the evaluation of serum angiotensin-converting enzyme for the diagnosis and management of sarcoidosis.

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DexamethasoneHumansHyperthyroidismHypothyroidismMacrophagesMonocytesPeptidyl-Dipeptidase AThyroiditisThyroxineTriiodothyronineJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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E Silverstein, G C Schussler, J Friedland. 1983. Elevated serum angiotensin-converting enzyme in hyperthyroidism.. https://doi.org/10.1016/0002-9343(83)91198-1

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