Lead activates calmodulin sensitive processes.

G W Goldstein; D Ar

doi:10.1016/0024-3205(83)90757-9

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Lead activates calmodulin sensitive processes.

G W Goldstein·D Ar

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Abstract

The effect of lead on two calcium sensitive processes was determined. Micromolar concentrations of lead successfully replaced calcium in the activation of calmodulin-sensitive phosphodiesterase and in the promotion of potassium loss from erythrocytes. Both actions of lead were blocked by trifluoperazine--an inhibitor of calmodulin function. We propose that some of the toxic effects of lead may be explained by its interaction with calmodulin.

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3',5'-Cyclic-AMP Phosphodiesterases Calcium Calcium-Binding Proteins Calmodulin Enzyme Activation Erythrocytes Humans Lead Potassium Trifluoperazine Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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G W Goldstein, D Ar. 1983-09-05. Lead activates calmodulin sensitive processes.. https://doi.org/10.1016/0024-3205(83)90757-9

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