Age-dependent decrease of beta-adrenoceptor density in the submandibular glands of mice and its modulation by the thymus.

P Fattoretti; C Viticchi; L Piantanelli

doi:10.1016/0167-4943(82)90024-3

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Age-dependent decrease of beta-adrenoceptor density in the submandibular glands of mice and its modulation by the thymus.

P Fattoretti·C Viticchi·L Piantanelli

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Abstract

Beta-adrenergic receptors were characterized in submandibular glands of ageing mice and old mice grafted with a neonatal thymus. No statistically significant changes of receptor affinity were found in the animal models investigated. On the contrary, receptor density showed a progressive decrease with advancing age. The age-related decrease has been found partially corrected in thymus-grafted old animals, which show a statistically significant recovery of receptor density when compared to their untreated littermates. Receptor modulation can be responsible for the age-related impairment and the thymus-dependent correction of beta-adrenergic responsiveness of submandibular glands previously observed in vivo. Hormonal balance and thyroid hormones, in particular, are suggested as being involved in the age- and thymus-dependent regulation of receptor density. In the accompanying Appendix, we describe the mathematical method used to calculate both specific and nonspecific binding from total binding data.

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Aging Animals Mice Mice, Inbred BALB C Mice, Nude Receptors, Adrenergic Receptors, Adrenergic, beta Submandibular Gland Thymus Gland Journal Article

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P Fattoretti, C Viticchi, L Piantanelli. 1982. Age-dependent decrease of beta-adrenoceptor density in the submandibular glands of mice and its modulation by the thymus.. https://doi.org/10.1016/0167-4943(82)90024-3

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