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Chronic ethanol changes opiate receptor function in rat striatum.

L Lucchi·R A Rius·H Uzumaki·S Govoni·M Trabucchi
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Abstract

Ethanol produces supersensitivity of striatal delta-opiate receptor sites labeled by [3H]DADLE and [3H]etorphine. The impairment may be ascribed to the diminished enkephalin release detected in rat striatum after chronic ethanol consumption. On the contrary, a lower affinity of striatal mu-opiate receptors results after same ethanol exposure. In fact, the Kd values of [3H]Met-enkephalin and [3H]DHM are enhanced when measured in striata of ethanol-dependent rats. The diverse sensitivity of the various classes of opiate receptors to ethanol may be ascribed to different ethanol effects on enkephalinergic transmission.

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AnimalsCorpus StriatumDihydromorphineEnkephalin, LeucineEnkephalin, Leucine-2-AlanineEnkephalin, MethionineEthanolEtorphineMaleRatsReceptors, OpioidJournal Article

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L Lucchi, R A Rius, H Uzumaki, S Govoni, M Trabucchi. 1984-02-20. Chronic ethanol changes opiate receptor function in rat striatum.. https://doi.org/10.1016/0006-8993(84)91245-9

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