Ruminant globin gene structures suggest an evolutionary role for Alu-type repeats.

J C Schimenti; C H Duncan

doi:10.1093/nar/12.3.1641

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Ruminant globin gene structures suggest an evolutionary role for Alu-type repeats.

J C Schimenti·C H Duncan

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Abstract

Bovine fetal and adult globin genes were cloned and subjected to DNA sequence analysis. Both of these genes contained insertions of Alu-type repetitive DNA within their introns. Comparison of cow and goat beta-type globin genes indicates that intragenic DNA insertions played a role in their evolution. These data support the theory that Alu-type repeats maintain genetic diversity by inhibiting gene conversion.

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Amino Acid Sequence Animals Base Sequence Biological Evolution Cattle Cloning, Molecular DNA Transposable Elements Fetus Genes Globins Goats Nucleic Acid Hybridization Repetitive Sequences, Nucleic Acid Species Specificity Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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J C Schimenti, C H Duncan. 1984-02-10. Ruminant globin gene structures suggest an evolutionary role for Alu-type repeats.. https://doi.org/10.1093/nar%2F12.3.1641

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