Isolation of a cDNA clone coding for an SB beta-chain.

K Gustafsson; E Emmoth; E Widmark; J Böhme; P A Peterson; L Rask

doi:10.1038/309076a0

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Isolation of a cDNA clone coding for an SB beta-chain.

K Gustafsson·E Emmoth·E Widmark·J Böhme·P A Peterson·L Rask

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Abstract

Class II antigens of the major histocompatibility complex (MHC) consist of a family of closely related cell surface-expressed glycoproteins. These antigens, which are genetically polymorphic, control important aspects of the immune response. At least three types of human class II antigens, namely, DR, DC and SB (refs 2-4), have been identified. All class II antigens are heterodimers composed of one alpha- and one beta-chain. The genes for both types of subunits are encompassed within the MHC. The general features of the DC and DR antigens have recently been elucidated. Much less is known, however, about the SB molecules. Here we describe the isolation of a cDNA clone as well as a genomic clone encoding a beta-chain whose amino acid sequence is compatible with the partial amino-terminal sequence of SB beta-chains.

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Amino Acid Sequence Base Sequence Cloning, Molecular DNA DNA Restriction Enzymes Genes, MHC Class II HLA-DP Antigens Histocompatibility Antigens Class II Humans Macromolecular Substances Major Histocompatibility Complex Nucleic Acid Hybridization Protein Biosynthesis Journal Article Research Support, Non-U.S. Gov't

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K Gustafsson, E Emmoth, E Widmark, J Böhme, P A Peterson, L Rask. Isolation of a cDNA clone coding for an SB beta-chain.. https://doi.org/10.1038/309076a0

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