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Oophorectomy leads to a selective decrease in 1,25-dihydroxycholecalciferol receptors in rat jejunal villous cells.

S D Chan·D K Chiu·D Atkins
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Abstract

The distribution of 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] receptors in isolated rat jejunal cells was investigated in normal and oophorectomized female rats and also in vitamin D-deficient animals. Oophorectomy caused a selective reduction in 1,25-(OH)2D3 receptor numbers in villous cells, the reduction being similar (37%) in both normal and vitamin D-deficient animals. The data suggest that this effect of oophorectomy reflects a direct effect of oestrogens in the intestinal synthesis of 1,25-(OH)2D3 receptors, independent of the renal synthesis of 1,25-(OH)2D3. It is proposed that this phenomenon may, in part, explain the reduction in calcium absorption which occurs after oophorectomy or the menopause.

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AnimalsCastrationFemaleIntestinal MucosaJejunumMaleRatsRats, Inbred StrainsReceptors, CalcitriolReceptors, SteroidVitamin D DeficiencyJournal ArticleResearch Support, Non-U.S. Gov't

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S D Chan, D K Chiu, D Atkins. 1984. Oophorectomy leads to a selective decrease in 1,25-dihydroxycholecalciferol receptors in rat jejunal villous cells.. https://doi.org/10.1042/cs0660745

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