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PubMed · 6327399

Differential antigen presentation in tumor immunity.

S Schatten·J A Drebin·R D Granstein·M I Greene
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Abstract

The tumor S1509a elicits a cell-mediated immune response in immune A/J mice but leads to the generation of suppressor T cells (Ts) in nonimmune mice. Previous studies have shown that I-A+ antigen-presenting cells (APC) present S1509a tumor antigen and thereby activate immune T cells. Recent studies with polyoma-induced tumors reveal similar findings. Administration of anti-I-A antibodies not only prevents effective T cell activation by I-A+ APC bearing S1509a tumor antigen but also induces Ts after a tumor challenge. Ts, which inhibit S1509a tumor immunity, may be activated by tumor antigen presented on I-J+ APC. Examination of the immunologic effects of cyclophosphamide and UV radiation supports this hypothesis.

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AnimalsAntibodies, MonoclonalAntigens, NeoplasmCyclophosphamideFibrosarcomaH-2 AntigensHistocompatibility Antigens Class IIHypersensitivity, DelayedImmune SeraImmunity, CellularMiceMice, Inbred AModels, BiologicalNeoplasms, ExperimentalNeoplasms, Radiation-InducedPolyomavirusSkin NeoplasmsT-LymphocytesT-Lymphocytes, RegulatoryTumor Virus InfectionsUltraviolet RaysJournal ArticleReview

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S Schatten, J A Drebin, R D Granstein, M I Greene. 1984. Differential antigen presentation in tumor immunity.. https://pubmed.ncbi.nlm.nih.gov/6327399/

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