Ethanol effects on striatal neuron activity.

E P Schoener

doi:10.1111/j.1530-0277.1984.tb05508.x

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Ethanol effects on striatal neuron activity.

E P Schoener

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Abstract

Cellular effects of ethanol were investigated in the rat neostriatum with local perfusion and extracellular, single unit recording techniques. Neuronal activity was modulated specifically as a function of ethanol concentration over a wide test range. At extremely low doses (10(-9) and 10(-8) M), the neuronal responses to drug perfusion were exclusively excitatory. However, at the highest doses examined (10(-8) and 10(-4) M), the results were reversed. In the midrange, a number of apparently ineffective tests were obtained, along with bimodal (excitation followed by depression) responses. The unequivocal responsiveness to ethanol at very low concentrations raises the possibility of a physiological role for the endogenous substance.

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Animals Corpus Striatum Dopamine Dose-Response Relationship, Drug Ethanol Male Neurons Rats Rats, Inbred Strains Reaction Time Synaptic Transmission Journal Article Research Support, U.S. Gov't, P.H.S.

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E P Schoener. Ethanol effects on striatal neuron activity.. https://doi.org/10.1111/j.1530-0277.1984.tb05508.x

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