Do prostaglandins affect cellular radiosensitivity in vitro?

B C Millar; S Jinks

doi:10.1080/09553008414551541

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Do prostaglandins affect cellular radiosensitivity in vitro?

B C Millar·S Jinks

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Abstract

We have been unable to detect any change in the in vitro radiation response of mouse fibrosarcoma cells, HSDM1C1, which secrete 2 micrograms PGE2/mg cell protein/24 h, in the presence of the prostaglandin biosynthesis inhibitor flurbiprofen. Furthermore, addition of exogenous PGE1 or PGA2 to cultures of Chinese hamster cells was similarly without effect on radiation response. Although a high concentration of PGA2 inhibited the growth of Chinese hamster cells in vitro this effect disappeared upon removal of the prostaglandin. The implications of these results for radiotherapy are discussed.

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Animals Cell Division Cell Line Cell Survival Cricetinae Cricetulus Flurbiprofen Gamma Rays Glutathione Hypoxia Mice Prostaglandins Prostaglandins A Prostaglandins E Sarcoma, Experimental Journal Article Research Support, Non-U.S. Gov't

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B C Millar, S Jinks. 1984. Do prostaglandins affect cellular radiosensitivity in vitro?. https://doi.org/10.1080/09553008414551541

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