Effect of verapamil on left ventricular function: a randomized, placebo-controlled study.

R E Vlietstra; M A Farias; R L Frye; H C Smith; E L Ritman

doi:10.1016/0002-9149(83)90371-5

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Effect of verapamil on left ventricular function: a randomized, placebo-controlled study.

R E Vlietstra·M A Farias·R L Frye·H C Smith·E L Ritman

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Abstract

Verapamil has a negative inotropic action in isolated cardiac muscle. Its effects on left ventricular function were tested in 25 patients with suspected coronary artery disease. A double-blind, randomized, placebo-controlled study design was used. Verapamil (0.2 mg/kg over 10 minutes) significantly lowered mean arterial pressure (from 105 to 89 mm Hg) while increasing the cardiac index (from 2.8 to 3.1 liters/min/m2). No statistically significant effect was seen on heart rate, left ventricular end-diastolic pressure or end-systolic volume index, ejection fraction, peak rates of systolic wall thickening or diastolic wall thinning, or percentage of hemiaxial shortening. However, there was a small increase in the left ventricular end-diastolic volume index (from 94 to 102 ml/m2). Important findings were a reduction in systemic vascular resistance (from 39 to 30 U . m2), an increase in left ventricular end-diastolic volume index consistent with a negative inotropic effect, and no evidence of improved regional wall dynamics in portions of the left ventricular wall considered hypokinetic because of myocardial ischemia.

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Cardiac Catheterization Clinical Trials as Topic Coronary Angiography Coronary Disease Female Heart Heart Ventricles Hemodynamics Humans Male Middle Aged Placebos Random Allocation Verapamil Clinical Trial Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

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R E Vlietstra, M A Farias, R L Frye, H C Smith, E L Ritman. 1983. Effect of verapamil on left ventricular function: a randomized, placebo-controlled study.. https://doi.org/10.1016/0002-9149(83)90371-5

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