Gender and propranolol-ethanol interaction.

F S Messiha; L Lutherer

PubMed · 6346130

Gender and propranolol-ethanol interaction.

Abstract

The in vitro effect of propranolol, a beta-receptor blocking agent, on specific activity of hepatic alcohol dehydrogenase (L-ADH) and aldehyde dehydrogenase (L-ALDH) was studied in the male and in the female rat. The presence of propranolol, in the dose range of 3 x 10(-4) M to 10(-3) M concentration in the reaction mixture noncompetitively inhibited female but not male L-ADH. Conversely, significant enhancement of mitochondrial but not cytoplasmic L-ALDH occurred in the presence of propranolol, between 10(-3) M and 10(-5) M concentration, in both sexes. The alteration of hepatic ethanol and acetaldehyde metabolizing enzymes by propranolol suggest both gender difference and possible contraindication of use of this drug in alcoholic patients.

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Acetaldehyde Alcohol Dehydrogenase Alcohol Oxidoreductases Aldehyde Dehydrogenase Aldehyde Oxidoreductases Animals Dose-Response Relationship, Drug Enzyme Activation Ethanol Female Liver Male Propranolol Rats Rats, Inbred Strains Sex Factors Journal Article

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F S Messiha, L Lutherer. Gender and propranolol-ethanol interaction.. https://pubmed.ncbi.nlm.nih.gov/6346130/

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