PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 6349229

Endocrine function and antiepileptic treatment.

K Lühdorf
View original source ↗Export metadata ↓

Abstract

A short survey on the influence of antiepileptic drugs on endocrine function is given. Although most antiepileptic drugs interfere with endocrine function, patients on antiepileptic drugs seldom experience any endocrine symptoms. In spite of this some knowledge on changed endocrine function in the epileptic patient is important for the clinician especially to avoid misinterpretation of endocrine parameters. Also the interaction between antiepileptic drugs and hormonal drugs especially oral contraceptives has practical importance.

Explore related subjects

AnticonvulsantsBlood GlucoseDrug InteractionsEpilepsyHormonesHumansHydrocortisoneHypothalamo-Hypophyseal SystemInsulinTestosteroneThyroid HormonesJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

K Lühdorf. 1983. Endocrine function and antiepileptic treatment.. https://pubmed.ncbi.nlm.nih.gov/6349229/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

A double-blind placebo-controlled trial of zonisamide (zonegran) in the treatment of essential tremor.

Medical therapy for essential tremor (ET), a common movement disorder, is often inadequate. We performed a double-blind placebo-controlled randomized trial to evaluate the efficacy and tolerability of zonisamide (ZNS), an antiepileptic agent, in treating ET. Twenty patients (mean age, 60 +/- 15 years) with ET were randomized to receive ZNS or placebo. ZNS was initiated at a dosage of 100 mg/day and escalated to 200 mg/day at day 14. Patients were evaluated by accelerometry and the Fahn-Tolosa-Marin (FTM) rating scale at baseline and days 14 and 28, as well as the Clinical Global Impression (CGI-C) scale at day 28. At endpoint, subjects assigned to ZNS were taking a mean dosage of 160 +/- 50 mg/day. There were no significant improvements in the FTM total score or its subsections. Tremor amplitude as assessed by accelerometry significantly improved in the ZNS group compared to the placebo group at endpoint relative to baseline (-0.50 +/- 0.72 vs. 0.30 +/- 0.79 m/s(2); P = 0.03). On the CGI-C, 60% (n = 6) of patients in the ZNS group felt that their tremor was unchanged, while the remaining patients felt that their tremor was "minimally improved." Thirty percent (n = 3) of patients taking ZNS discontinued the study due to side effects (fatigue, headache, paresthesias) while taking 100 mg per day. ZNS did not provide significant improvements in clinical rating scales at study endpoint compared to placebo and was only modestly well tolerated. ZNS was effective in reducing tremor amplitude as measured by accelerometry.

Anticonvulsants↗