Protein-binding polyhedral boranes.

R L Sneath; J E Wright; A H Soloway; S M O'Keefe; A S Dey; W D Smolnycki

doi:10.1021/jm00233a007

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Protein-binding polyhedral boranes.

R L Sneath·J E Wright·A H Soloway·S M O'Keefe·A S Dey·W D Smolnycki

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Abstract

A series of polyhedral borane derivatives containing protein-binding functional groups has been synthesized. Problems encountered in earlier studies (low incorporation levels, gross precipitation of conjugates) have been overcome by including a water-solubilizing gluconamide group in the structure. This modification has allowed high levels of boron to be covalently bound to HGG, forming a completely water-soluble conjugate.

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Boranes Humans In Vitro Techniques Protein Binding Proteins Structure-Activity Relationship gamma-Globulins Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

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R L Sneath, J E Wright, A H Soloway, S M O'Keefe, A S Dey, W D Smolnycki. 1976. Protein-binding polyhedral boranes.. https://doi.org/10.1021/jm00233a007

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