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PubMed · 6365644

Insulin release : the fuel concept.

W J Malaisse
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Abstract

Insulin release evoked by nutrient secretagogues invariably coincides with an increase in the catabolism of exogenous and/or endogenous nutrients in pancreatic islet cells, resulting in an increased generation rate of reducing equivalents and ATP, and an increase in O2 consumption. This situation was documented in response to a number of carbohydrates, including the anomers of D-glucose and D-mannose, various 2-keto acids, including pyruvate and its poorly oxidized phenylated analog 3-phenylpyruvate, and selected amino acids, including the nonmetabolized analog of L-leucine 2-aminobicyclo[2, 2, 1]heptane-2-carboxylic acid. These convergent observations indicate that the B-cell should be considered as a fuel-sensor organ. Further progress in this field requires both the identification of those circulating nutrients used by the B-cell whether in the resting or stimulated state, and a better understanding of the coupling between the generation of second messengers (H+, NAD(P)H, ATP) and more distal events in the secretory sequence, such as the remodelling of ionic fluxes across the plasma membrane and within the pancreatic B-cell.

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Amino AcidsCaproatesEnergy MetabolismGlucose-6-PhosphateGlucosephosphatesGlycolysisHexosesHumansInsulinInsulin SecretionIslets of LangerhansKeto AcidsLeucineModels, BiologicalNorleucinePhenylpyruvic AcidsPyruvatesPyruvic AcidStereoisomerismStructure-Activity RelationshipJournal ArticleResearch Support, Non-U.S. Gov'tReview

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W J Malaisse. 1983. Insulin release : the fuel concept.. https://pubmed.ncbi.nlm.nih.gov/6365644/

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