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Behaviour in ferrets of swine influenza virus isolated from man.

G L Toms·C Sweet·H Smith
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Abstract

After intranasal instillation into ferrets, the "swine" influenza virus A/New Jersey/8/76(Hsw1 N1) had a 50% minimal infectious dose similar to that of previously tested A/PR/8-A/England (H3 N2) recombinants virulent and attenuated for man. A/New Jersey produced only a mild upper respiratory tract infection. However, higher titres of virus were recovered from the lungs over a longer period than experienced previously with Asian and Hong Kong virus strains. There was a diphasic pyrexia the second and higher peaks of which correlated with peak titres of virus in lung macerates. These results suggest that A/New Jersey has a pneumotropic potential in ferrets and, if the animal model is valid, possible in man.

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AnimalsCarnivoraDisease Models, AnimalFerretsFeverHumansInfluenza A virusInfluenza, HumanLungNosePneumonia, ViralVirulenceJournal Article

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G L Toms, C Sweet, H Smith. 1977-01-08. Behaviour in ferrets of swine influenza virus isolated from man.. https://doi.org/10.1016/s0140-6736(77)91081-9

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