Interactions between digitonin and bilayer membranes.

R G Miller

doi:10.1016/0005-2736(84)90286-4

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Interactions between digitonin and bilayer membranes.

R G Miller

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Abstract

The morphology of interactions between digitonin and cholesterol has been investigated. When precipitated from ethanolic solutions, digitonin-cholesterol complexes form in flat lamellar sheets. In contrast, when the complex is formed in a bilayer membrane, the membrane is deformed into corrugations of hemitubules. The polarity of the deformations formed in bilayer membranes is highly correlated with the direction of entry of digitonin into the membrane. We suggest that the morphology of digitonin/cholesterol hemitubules is dependent upon the complex being formed within a bilayer and, in addition, is not correlated with asymmetry of cholesterol concentration across the membrane.

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Animals Cholesterol Digitonin Erythrocyte Membrane Ethanol Freeze Fracturing Intestinal Mucosa Islets of Langerhans Lipid Bilayers Journal Article Research Support, Non-U.S. Gov't

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R G Miller. 1984-07-11. Interactions between digitonin and bilayer membranes.. https://doi.org/10.1016/0005-2736(84)90286-4

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