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Decrease in insulin secretion related to hypocalcemia induced by a high dose of zinc in rats.

M Yamaguchi·K Takahashi
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Abstract

A single oral administration of zinc (Zn), sufficient to induce hypocalcemia, caused a decrease in glucose tolerance in fasted rats. This decrease resulted from reduction of insulin secretion. The restoration of Zn-induced hypocalcemia completely prevented the decrease in glucose tolerance and insulin secretion. These results suggest that the effect of Zn administration on insulin secretion in rats is a consequence of hypocalcemia.

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Administration, OralAnimalsAtropineCalciumGlucose Tolerance TestHypocalcemiaInsulinInsulin SecretionMaleRatsRats, Inbred StrainsZincJournal Article

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M Yamaguchi, K Takahashi. 1984. Decrease in insulin secretion related to hypocalcemia induced by a high dose of zinc in rats.. https://doi.org/10.1016/0378-4274(84)90063-8

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