Developmental changes in rat liver alcohol dehydrogenase.

P J Lad; W J Shoemaker; H L Leffert

doi:10.1016/0012-1606(84)90310-5

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Developmental changes in rat liver alcohol dehydrogenase.

P J Lad·W J Shoemaker·H L Leffert

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Abstract

Hepatic alcohol dehydrogenase activity and mass content change coordinately during development in male rats. Enzyme activity and mass content increase continuously after birth to 100 and 80% of maximal values within 6 weeks (2.6 +/- 0.4 mumole/min/g liver and 92 +/- 20 micrograms/g liver), respectively. When expressed per milligram of soluble proteins, both parameters peak at 3 weeks (0.052 +/- 0.002 mumole/min/mg protein and 2.0 +/- 0.4 micrograms/mg protein) and then decrease gradually to plateau levels. These decreases probably arise from a "surge" in soluble liver protein levels that occurs after weaning. Similar developmental patterns also occur in female rats. These findings are the first quantitative measurements of this enzyme in developing animals.

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Aging Alcohol Dehydrogenase Alcohol Oxidoreductases Animals Female Liver Male Pregnancy Proteins Rats Rats, Inbred Strains Sex Factors Journal Article Research Support, U.S. Gov't, P.H.S.

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P J Lad, W J Shoemaker, H L Leffert. 1984. Developmental changes in rat liver alcohol dehydrogenase.. https://doi.org/10.1016/0012-1606(84)90310-5

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