PubMed · 638575
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
1978-04-22. Plasmapheresis.. https://pubmed.ncbi.nlm.nih.gov/638575/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Explore the source record for details and available documents.
Autoimmunity is now regarded as the unequivocally predominant pathogenic process underlying most forms of primary and secondary glomerulonephritis in humans, and a number of autoantibodies occurring in conjunction with glomerulonephritis have been discovered. However, apart from the anti-NC1 antibodies occurring in classic Goodpasture's syndrome, the exact pathogenic role of these autoantibodies in human glomerulonephritis remains to be established, though this in no way diminishes the importance of their study. They have been of enormous value in subclassifying glomerulonephritis, previously thought to be a homogeneous entity. Autoantibody analysis has become a vital aid in the early diagnosis of rapidly progressive glomerulonephritis, which in turn has enabled treatment to be started early, thus contributing to a decline in the morbidity and mortality resulting from these disorders. Moreover, investigation of these autoantibodies will be of immense value in future studies focused on the pathogenic mechanisms involved in glomerulonephritis.
We report a 6-year-old boy with anti-glomerular basement membrane nephritis (Goodpasture's syndrome). Intensive treatment with plasmapheresis and immunosuppression resulted in clearance of antibody and good recovery of renal function.