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PubMed · 63971

Mechanism of bleomycin sensitivity on Escherichia coli and its possible implication on cancer chemotherapy.

H Endo
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BleomycinCell LineCell Membrane PermeabilityChromosome MappingChromosomes, BacterialCrosses, GeneticDNA RepairDNA, BacterialDrug Resistance, MicrobialDrug SynergismEscherichia coliIn Vitro TechniquesLeucineMutationPolyenesRecombination, GeneticThymidineUridineComparative StudyJournal Article

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H Endo. 1976. Mechanism of bleomycin sensitivity on Escherichia coli and its possible implication on cancer chemotherapy.. https://pubmed.ncbi.nlm.nih.gov/63971/

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PubMed1979

Oxygenated iron bleomycin. A short-lived intermediate in the reaction of ferrous bleomycin with O2.

The reaction of Fe(II) . bleomycin with O2 to yield Fe(III) . bleomycin has been resolved into two kinetic events by stopped-flow spectrophotometry. The first event is first order with respect to both bleomycin and O2 and may be regarded as a second order reaction (k = 6.1 x 10(3) M-1s-1 at 2 degrees C). The first product has no EPR spectrum. The optical spectrum resembles those of Fe(II) . bleomycin complexes with CO, NO, and ethyl isocyanide. We propose that the first product is an Fe(II) . bleomycin . O2 complex. The second kinetic event is first order with respect to the first accumulated product (k = 0.11 s-1 at 2 degrees C) and independent of oxygen concentration. The product of this reaction is indistinguishable from Fe(III) . bleomycin by optical and EPR spectroscopy.

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