PubMed · 6400642
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F Vidal Vanaclocha. 1983. [Intercellular communication by coupling junctions].. https://pubmed.ncbi.nlm.nih.gov/6400642/
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OBJECTIVES: Randomized controlled trials offer the best chance for valid treatment comparisons, yet most trials are of poor quality. This may reflect a lack of awareness of the requirements for conducting and reporting this type of research. If so, then citation of methodology references might indicate knowledge of how to conduct these studies and vice versa. Our study tests the hypothesis that the methodologic quality of published trials is related to citation of methodology references. STUDY DESIGN: We performed a hand search of the American Journal of Obstetrics and Gynecology, the British Journal of Obstetrics and Gynaecology, the Journal of Obstetrics and Gynaecology, and Obstetrics and Gynecology to identify all randomized controlled trials published in 1990 and 1991 (N = 206). We reviewed the reference lists of all reports of randomized controlled trials and evaluated the adequacy of randomization methods by accepted criteria. RESULTS: Most reports (81.6%) cited no methodology text or article. Although lack of any methodology reference was not significantly related to failure to report an adequate random method of sequence generation, this was highly related (p < 0.001) to failure to report adequate allocation concealment. Scanning the reference list of reports took a mean of 16 seconds and identified most poorly done trials. CONCLUSIONS: Investigators who conduct randomized controlled trials should be thoroughly familiar with this type of research or should get expert help. Poorly done trials are wasteful and often misleading.
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From a systematic study of 500 references randomly selected in the January through July, 1992, issues of the Journal of Oral and Maxillofacial Surgery, it was found that 26% had errors. 6.2% of the referenced articles could not be found at all; either due to the fact that they were obscure foreign articles, their age made it difficult to verify, they cited non-peer reviewed journals, or the references cited journals that possibly did not exist. The remaining references were verified either from the original source or from other indexing tools if the original was not available.