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PubMed · 6400896

On the processivity of DNA replication.

F R Fairfield·J W Newport·M K Dolejsi·P H von Hippel
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Abstract

In this paper we describe the nature and importance of processive enzymatic reactions in biological processes. A model is set up to describe the processive synthetic process in DNA replication, and experiments are presented to define and test the model, using the components of the T4 phage-coded five-protein (in vitro) DNA replication system of Alberts. Nossal and coworkers. These experiments are performed either with a homogeneous oligo dT-poly dA primer-template system, or with a natural primer-template system using phage M13 DNA. The results are used to define some molecular aspects of the microscopic "processivity cycle".

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Base SequenceDNA ReplicationDNA, ViralDNA-Directed DNA PolymeraseMolecular Sequence DataT-PhagesJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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F R Fairfield, J W Newport, M K Dolejsi, P H von Hippel. 1983. On the processivity of DNA replication.. https://doi.org/10.1080/07391102.1983.10507477

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