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PubMed · 6409003

[Studies on biodegradable microspheres containing mitomycin C].

S Fujimoto·F Endoh·Y Kitsukawa·Y Morimoto·K Sugibayashi·K Okui
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Abstract

For the purpose of enhancing antitumor effects, we prepared heated albumin microspheres containing an antitumor drug, mitomycin C. The biodegradable MMC microspheres which have an average diameter of 45 +/- 8 mum contain approximately 10% of MMC and release in vitro approximately 20% of the MMC over 3-day period. The microspheres were injected into albino rabbit femoral artery of the hind leg into which a VX-2 tumor had been implanted. Peripheral blood levels of MMC were reduced as compared to the conventional MMC group, within 60 minutes after injection. Subsequently in the MMC-microsphere administered rabbits, the level was higher than in the conventional MMC administered group. The survival of VX-2 tumor-bearing rabbits prolonged markedly with MMC microspheres.

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AnimalsBiodegradation, EnvironmentalMicrospheresMitomycinMitomycinsNeoplasm TransplantationNeoplasms, ExperimentalRabbitsEnglish AbstractJournal Article

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S Fujimoto, F Endoh, Y Kitsukawa, Y Morimoto, K Sugibayashi, K Okui. 1983. [Studies on biodegradable microspheres containing mitomycin C].. https://pubmed.ncbi.nlm.nih.gov/6409003/

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