Brain 5-hydroxytryptamine level, metabolism, and binding in E1 mice.

M Hiramatsu

doi:10.1007/bf00964930

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PubMed · 6415506

Brain 5-hydroxytryptamine level, metabolism, and binding in E1 mice.

M Hiramatsu

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Abstract

Inbred E1 mice are highly susceptible to convulsive seizures upon "throwing" stimulation. The strain is known to have an abnormal 5-hydroxytryptamine (5-HT) metabolism. In the study here 5-HT level, [14C]5-hydroxytryptophan (5-HTP) metabolism, MAO activity and [3H]5-HT receptor binding were examined in the cortex, brainstem and cerebellum. In the interictal period cortical and brainstem 5-HT level and [3H]5-HT receptor binding were significantly lower. In the same period cortical biosynthesized [14C]5-HT from [14C]5-HTP taken up was higher, and MAO activity was not changed. L-DOPA with MK486 induced a low threshold of seizures and decreased cortical 5-HT level. Abnormally functioning 5-HT neurones may exist in the E1 mouse cortex.

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5-Hydroxytryptophan Animals Brain Brain Chemistry Carbidopa Dihydroxyphenylalanine Mice Mice, Inbred Strains Monoamine Oxidase Physical Stimulation Serotonin Journal Article Research Support, Non-U.S. Gov't

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M Hiramatsu. 1983. Brain 5-hydroxytryptamine level, metabolism, and binding in E1 mice.. https://doi.org/10.1007/bf00964930

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