Immunoglobulin heavy chain binding protein.

I G Haas; M Wabl

doi:10.1038/306387a0

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PubMed · 6417546

Immunoglobulin heavy chain binding protein.

I G Haas·M Wabl

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Abstract

Pre-B lymphocytes, and hybridomas derived from them, synthesize immunoglobulin heavy (IgH) chain in the absence of light (L) chain. In the Abelson virus transformed line 18-81, which is representative of the pre-B cell stage, we observed that at least some of the H-chains are bound to a protein other than L-chain. Here we show that the protein (which we term immunoglobulin heavy-chain binding protein, BiP) binds non-covalently to free IgH, but not to IgH associated with IgL.

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Animals B-Lymphocytes Carrier Proteins Endoplasmic Reticulum Chaperone BiP Heat-Shock Proteins Immunoglobulin Heavy Chains Immunoglobulin Light Chains Mice Molecular Chaperones Molecular Weight Myeloma Proteins Peptide Fragments Journal Article

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I G Haas, M Wabl. Immunoglobulin heavy chain binding protein.. https://doi.org/10.1038/306387a0

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