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PubMed · 6430877

Panic anxiety: a new biological model.

D B Carr·D V Sheehan
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Abstract

Previously unrecognized similarities among metabolic responses to various maneuvers used to evoke anxiety in patients with panic disorder are described. On the basis of these observations, a new biological model is proposed for panic disorder, in which the primary defect--which is neuroendocrine rather than psychiatric--is operationally placed within the redox-regulating apparatus of the brain stem. This model is consistent with many clinical features of panic disorder and also provides a theoretical framework for further studies of the pathophysiology of this and related conditions (e.g., hyperventilation syndrome).

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Anxiety DisordersBrain StemCarbon DioxideFearHumansHyperventilationLactatesLactic AcidModels, BiologicalNorepinephrineOxidation-ReductionPanicPyruvatesSympathetic Nervous SystemJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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D B Carr, D V Sheehan. 1984. Panic anxiety: a new biological model.. https://pubmed.ncbi.nlm.nih.gov/6430877/

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