[Enzymatic lipid peroxidation].

V Z Lankin

PubMed · 6431673

[Enzymatic lipid peroxidation].

Abstract

Biosynthesis of certain biologically active substances (prostaglandins, thromboxanes, prostacyclins and leukotrienes) in animal tissues occurs with participation of cyclooxygenases and lipoxygenases, enzymic systems of lipid peroxidation. In normal physiological and pathological processes the enzymic lipid peroxidation by microsomal dioxygenases is considerably more active than the nonenzymic one in the same membrane structures. The molecular structure of the products of the enzymic and nonenzymic peroxidation of lipids also differs essentially. An assumption is advanced that cytosol lipoxygenase may be an easily dissociating component of the cyclooxygenase multienzymic complex and its transition from the biomembrane to the cell cytoplasm is accompanied by changes in the enzyme conformation and chemical nature of the products resulted from polyenic lipids oxidation catalyzed by the enzyme.

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Animals Enzyme Activation Fatty Acids, Essential Free Radicals Humans Kinetics Lipid Peroxides Lipoxygenase Mice Microsomes, Liver Multienzyme Complexes Oxidation-Reduction Phospholipases A Prostaglandin-Endoperoxide Synthases Rabbits Rats Glycine max Substrate Specificity Journal Article

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V Z Lankin. [Enzymatic lipid peroxidation].. https://pubmed.ncbi.nlm.nih.gov/6431673/

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