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PubMed · 6434197

Artefactual decrease in total protein concentration in patients with monoclonal gammopathies: a method-dependent error.

K J Whitlow·A A Nanji·M R Pudek
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Abstract

We found total protein estimates in patients with monoclonal gammopathies to be erroneously low when using the Cobas-Bio centrifugal analyzer. This problem occurred only when a serum-water blank was used. This probably results from the precipitation of these proteins under conditions of low ionic strength resulting in high blank readings. The problem can be avoided if a serum-saline blank is used.

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K J Whitlow, A A Nanji, M R Pudek. 1984. Artefactual decrease in total protein concentration in patients with monoclonal gammopathies: a method-dependent error.. https://doi.org/10.1016/s0009-9120(84)90123-1

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