[Fluorinated pyrimidines--administration methods].

H Furue

Home/Archive/PubMed

PubMed · 6437342

[Fluorinated pyrimidines--administration methods].

H Furue

View original source ↗Export metadata ↓

Abstract

In spite of the fact that fluorinated pyrimidines have been in extensive clinical use for more than 25 years, the optimal dose, route of administration and schedule have yet to be determined. An adequate course is considered to be one that produces either an objective response or mild toxicity. However, modification of dose schedule have shown considerable variation in rate of response, drug toxicity, and drug mortality. In contrast to its rapid clearance from blood, 5-fluorouracil may persist for prolonged period in cancer tissue. More detailed measurements of their metabolites in cancer tissue may lead to an improved understanding of 5-fluorouracil treatment.

Explore related subjects

Drug Administration Schedule Fluorouracil Humans Infusions, Parenteral Neoplasms Tegafur English Abstract Journal Article

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

H Furue. 1984. [Fluorinated pyrimidines--administration methods].. https://pubmed.ncbi.nlm.nih.gov/6437342/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1995

Surfactant replacement therapy in neonatal respiratory distress syndrome.

Explore the source record for details and available documents.

Drug Administration Schedule↗

PubMed1995

A general model of drug prescription.

Currently, there is no widely accepted structured representation of drug prescription. Nevertheless, a structured representation is required for entering and storing drug prescriptions avoiding free text in computerized systems, and for drug prescription reviews. Derived from part of the work of the European OPADE project, we describe an object-oriented model of drug prescription which incorporates important concepts such as the phase and triggering event concepts. This model can be used to record all drug prescriptions, including infusions, in a structured way avoiding free text. The phase concept allows the storage of sequentially ordered dosage regimens for a drug within the same prescription. The prescription triggering event concept allows recording of the administration of a drug conditional to dates, symptoms and clinical signs, medical procedures, and everyday life events. This model has been implemented within the OPADE project; the corresponding aspects of the user interface are presented to show how this model can be used in practice. Even if other new attributes may be added to the described objects, the structure of this model is suitable for general use in software which requires the entry, storage and processing of drug prescriptions.

Drug Administration Schedule↗

PubMed1995

Modeling drug information for a prescription-oriented knowledge base on drugs.

There exists little theoretical analysis how to represent knowledge on drugs required for computerized drug-prescription applications. A work package drug information modeling is described which was part of the European OPADE project. We describe the content and structure of a Drug Knowledge Base (DKB) designed to meet the requirements of decision-support systems in the domain of drug therapy, and to facilitate data transfer from various information sources. The definition of the DKB content is derived from the analysis of information requirements at the various stages of the process of the clinical usage of drugs (prescribing, administration, and follow-up). The DKB structure results from the classification of the various data items along two dimensions: (1) entities in the pharmaco-therapeutic domain for which information must be defined (the PharmacoTherapeutic Group, the Component, the ManufacturedPreparation, and the Presentation), and (2) the validity score of the pharmaco-therapeutic information (international, national, or local).

Drug Administration Schedule↗