Structure of human factor VIII.

G A Vehar; B Keyt; D Eaton; H Rodriguez; D P O'Brien; F Rotblat; H Oppermann; R Keck; W I Wood; R N Harkins; E G Tuddenham; R M Lawn; D J Capon

doi:10.1038/312337a0

PubMed · 6438527

Structure of human factor VIII.

G A Vehar·B Keyt·D Eaton·H Rodriguez·D P O'Brien·F Rotblat·H Oppermann·R Keck·W I Wood·R N Harkins·E G Tuddenham·R M Lawn·D J Capon

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Abstract

The deduced amino acid sequence of human factor VIII, obtained from the DNA sequence, predicts a mature polypeptide of 2,332 amino acids containing a triplicated domain structure. The polypeptide has 35% sequence homology with the copper-binding plasma protein, ceruloplasmin. Determination of the thrombin cleavage sites in plasma-derived factor VIII polypeptides allows prediction of the domains involved in the associated activation and inactivation of the protein.

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Amino Acid Sequence Ceruloplasmin Factor VIII Humans Peptide Fragments Protein Conformation Protein Precursors Thrombin Comparative Study Journal Article Research Support, Non-U.S. Gov't

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G A Vehar, B Keyt, D Eaton, H Rodriguez, D P O'Brien, F Rotblat, H Oppermann, R Keck, W I Wood, R N Harkins, E G Tuddenham, R M Lawn, D J Capon. Structure of human factor VIII.. https://doi.org/10.1038/312337a0

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