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PubMed · 6444397

Platelet function during haemoperfusion in acute liver failure.

R D Hughes·D A Lane·G Cella·V V Kakkar·P G Langley·R Williams
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Abstract

The changes in platelet-related haemostatic parameters have been studied during haemoperfusion of eleven patients with acute liver failure. Five patients were treated by haemoperfusion with an albumin-coated resin column and six with a polymer-coated charcoal column. The platelet and white cell losses over four hours' haemoperfusion were small in both groups. Significant increases in beta-thromboglobulin (mean 341 +/- SE 145 ng/ml) were seen after one hour in the patients treated by charcoal haemoperfusion. One patient in the charcoal group with the greatest rises in beta-thromboglobulin (860 ng/ml) and screen filtration pressure (205 mmHg) developed severe hypotension and haemoperfusion was terminated after 1 hour. One patient in the resin group showed rapid consumption of heparin after 2 hours. Measurement of beta-thromboglobulin is a sensitive assay of platelet activation during haemoperfusion. Albumin-coated resin haemoperfusion appears to be a more blood-compatible procedure with respect to platelets than charcoal haemoperfusion.

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Acrylic ResinsBlood PlateletsCharcoalFiltrationHemoperfusionHeparinHepatic EncephalopathyHumansPlatelet AggregationPlatelet CountPlatelet Factor 4PolystyrenesPressurebeta-ThromboglobulinJournal Article

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R D Hughes, D A Lane, G Cella, V V Kakkar, P G Langley, R Williams. 1980. Platelet function during haemoperfusion in acute liver failure.. https://pubmed.ncbi.nlm.nih.gov/6444397/

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