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PubMed · 644460

Reoperative parathyroid surgery for persistent hyperparathyroidism.

M F Brennan·J L Doppman·S J Marx·A M Spiegel·E M Brown·G D Aurbach
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Abstract

In a 2-year period 30 patients with persistent hyperparathyroidism following 59 prior unsuccessful procedures underwent reoperation. Preoperative arteriography was useful in planning the surgical approach in 56%, and retrospectively was correct in 63%. Selective venous catheterization gave localizing information in 83%, correctly predicting site or side in 60% of the total. Computerized axial tomography was helpful in identifying mediastinal glands before operation. Reoperation was successful in rendering the patient hypocalcemic or normocalcemic in 83%. Of the 11 patients (37%) who were rendered profoundly hypocalcemic, two were subsequently weaned from vitamin D and calcium support; seven have received either fresh or cryopreserved parathyroid autografts. Persistent hyperparathyroidism is a difficult surgical problem which we believe warrants aggressive localization attempts prior to operation. Autotransplantation with cryopreserved parathyroid tissue may be of value in the long-term management of the high incidence of postoperative hypocalcemia in this patient group.

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AdenomaAdolescentAdultAgedAngiographyChildFemaleHumansHyperparathyroidismHypocalcemiaMaleMediastinumMiddle AgedParathyroid GlandsParathyroid NeoplasmsPhlebographyTomography, X-Ray ComputedTransplantation, AutologousJournal Article

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M F Brennan, J L Doppman, S J Marx, A M Spiegel, E M Brown, G D Aurbach. 1978. Reoperative parathyroid surgery for persistent hyperparathyroidism.. https://pubmed.ncbi.nlm.nih.gov/644460/

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