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Suppressor cell loss and dysfunction in mixed connective tissue disease.

D Alarcón-Segovia·A Ruíz-Arguelles
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Abstract

Of 11 patients with untreated mixed connective tissue disease (MCTD) who were studied, all had decreased circulating T gamma cells, and all but one had decreased suppressor cell function of T cells on B cells, determined by a reverse hemolytic plaque-cell assay. Results in 21 normal subjects were significantly, different. Incubation of mononuclear cells from MCTD patients in purified anti-ribonucleoprotein (anti-RNP) IgG resulted in further decrease in their suppressor function. Decrease of T gamma cells and their suppressor function may be due to in vivo penetration of anti-RNP antibody into T gamma cells, causing their deletion.

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Antibodies, AntinuclearHemolytic Plaque TechniqueHumansLeukocyte CountMixed Connective Tissue DiseaseT-LymphocytesT-Lymphocytes, RegulatoryJournal Article

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D Alarcón-Segovia, A Ruíz-Arguelles. 1980. Suppressor cell loss and dysfunction in mixed connective tissue disease.. https://doi.org/10.1002/art.1780230308

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