Ability of thymosin to decrease in vivo and in vitro suppressor cell activity in tumor bearing mice and cancer patients.

B Serrou; D Cupissol; J Caraux; C Thierry; C Rosenfeld; A L Goldstein

doi:10.1007/978-3-642-81491-4_18

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Ability of thymosin to decrease in vivo and in vitro suppressor cell activity in tumor bearing mice and cancer patients.

B Serrou·D Cupissol·J Caraux·C Thierry·C Rosenfeld·A L Goldstein

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Abstract

We have demonstrated that splenic lymphocytes from normal syngeneic animals can stimulate tumor growth. This effect is T-cell dependent. Preincubation of these lymphocytes with thymosin not only blocks facilitated tumor growth but can induce a significant reduction of local tumor growth and number of pulmonary metastases. Furthermore, thymosin can also block the expression of suppressor activity of lymphocytes either stimulated by Con A or originating from various advanced solid tumor bearing patients. These results therefore suggest that thymosin is able to modulate, directly or indirectly, functional expression of suppressor cells.

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Animals Humans In Vitro Techniques Lymphocytes Mice Neoplasms Neoplasms, Experimental Rosette Formation T-Lymphocytes, Regulatory Thymosin Thymus Hormones Journal Article

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B Serrou, D Cupissol, J Caraux, C Thierry, C Rosenfeld, A L Goldstein. 1980. Ability of thymosin to decrease in vivo and in vitro suppressor cell activity in tumor bearing mice and cancer patients.. https://doi.org/10.1007/978-3-642-81491-4_18

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