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B lymphocyte function in B cell chronic lymphocytic leukaemia.

J A Wolos·F R Davey
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Abstract

B-enriched lymphocyte populations from patients with chronic lymphocytic leukaemia (CLL) were compared to B-enriched lymphocyte populations from normal age-matched controls for their ability to stimulate a proliferative response and to generate cytotoxic cells in allogeneic mixed lymphocyte cultures (MLC). The proliferative responses of MLCs were less than normal when the stimulating cells originated from B cells of patients with CLL. The degree of stimulation provided by the B cells from the patients with CLL inversely correlated with the peripheral white cell count. Lymphocytes from patients providing a poor stimulatory signal in the MLC tended to have less "Ia-like" antigen than lymphocytes giving a moderate level of stimulation. B lymphocytes from patients with CLL which stimulated poorly in the MLC also failed to generate specific cytotoxic cells even when provided with a normal proliferative trigger. These data suggest that B lymphocytes from cases of CLL with markedly elevated leucocyte counts may have a diminished concentration of both "Ia-like" and serum defined antigens.

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B-LymphocytesCell DivisionCytotoxicity, ImmunologicHLA-D AntigensHistocompatibility Antigens Class IIHumansLeukemia, LymphoidLeukocyte CountLymphocyte Culture Test, MixedJournal Article

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BibTeXRIS

J A Wolos, F R Davey. 1981. B lymphocyte function in B cell chronic lymphocytic leukaemia.. https://doi.org/10.1111/j.1365-2141.1981.tb07242.x

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