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PubMed · 6461083

Potentiative interactions between caffeine and various teratogenic agents.

E J Ritter·W J Scott·J G Wilson·P R Mathinos·J L Randall
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Abstract

Acetazolamide and inhibitors of DNA synthesis (hydroxyurea, 5-fluoro-2'-deoxyuridine), RNA synthesis (actinomycin D), and protein synthesis (cycloheximide, emetine) were each administered to pregnant rats together with caffeine at doses where each agent alone caused minimal embryotoxicity. Caffeine co-administered with any of the other agents induced a powerful potentiative response. It is not clear from the present experiments whether much lower caffeine dosage, as normally encountered in humans, would potentiate embryotoxicity due to other agents.

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Abnormalities, Drug-InducedAcetazolamideAnimalsCaffeineCycloheximideDactinomycinDose-Response Relationship, DrugDrug SynergismEmetineFemaleFetal DeathFloxuridineHydroxyureaPregnancyRatsRats, Inbred StrainsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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E J Ritter, W J Scott, J G Wilson, P R Mathinos, J L Randall. 1982. Potentiative interactions between caffeine and various teratogenic agents.. https://doi.org/10.1002/tera.1420250113

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