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[Problems concerned with microbial mutagenicity tests].

D Gericke
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Abstract

Mutagenicity tests using microorganisms are the Salmonella-typhimurium test (Ames), the test with a polymerase A deficient Escherichia coli, the Saccharomyces cerevisiae D3 system and the Neurospora crassa test. Differences in results of Ames-test may be due to differences preserving the tester strains, the choice of solvent and the dosage of the test compounds, last not least is the production of S-9. The polymerase A deficient Escherichia coli system seems easier to handle than the Saccharomyces cerevisiae- or Neurospora crassa-test. The metabolic activation with different forms of S-9 is needed in the Salmonella- and the Escherichia coli-system. Nevertheless it is not possible to decide if a substance is carcinogenic for human beings or animals with microbial mutagenicity tests only.

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CarcinogensDrug Evaluation, PreclinicalEscherichia coliHumansMutagenicity TestsMutagensMutationNeurospora crassaSaccharomyces cerevisiaeSalmonella typhimuriumComparative StudyJournal Article

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D Gericke. 1982. [Problems concerned with microbial mutagenicity tests].. https://doi.org/10.1159/000214962

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