Conformational variation in superhelical deoxyribonucleic acid.

A M Campbell

doi:10.1042/bj1710281

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Conformational variation in superhelical deoxyribonucleic acid.

A M Campbell

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Abstract

Sedimentation experiments have shown that superhelical DNA undergoes a sharp structural transition at low ionic strength. Light-scattering experiments show that this is due to a change in conformation of the DNA rather than to a change in interactions among DNA molecules. The results show that two possible conformations can occur for superhelical DNA under routine experimental conditions and may explain the discrepancies in the number of early unwinding sites exposed by different techniques.

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DNA, Superhelical Light Nucleic Acid Conformation Osmolar Concentration Scattering, Radiation Journal Article

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A M Campbell. 1978-04-01. Conformational variation in superhelical deoxyribonucleic acid.. https://doi.org/10.1042/bj1710281

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