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Lipopolysaccharides: structural principles and biologic activities.

O Lüderitz·K Tanamoto·C Galanos·G R McKenzie·H Brade·U Zähringer·E T Rietschel·S Kusumoto·T Shiba
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Abstract

Structural principles of the three regions of the lipopolysaccharide molecule are briefly discussed. One of the recently available, chemically synthesized lipid A analogues has been tested for biologic activities. The preparation was found to be toxic, pyrogenic, and mitogenic. The amounts, however, needed for expression of effects similar to those of lipid A were about 500 times higher. These investigations are aimed at verifying the proposed structure of lipid A and at evaluating structure-activity relationships.

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AnimalsLipid ALipopolysaccharidesMiceMitogensPyrogensRabbitsStructure-Activity RelationshipJournal ArticleResearch Support, Non-U.S. Gov't

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O Lüderitz, K Tanamoto, C Galanos, G R McKenzie, H Brade, U Zähringer, E T Rietschel, S Kusumoto, T Shiba. Lipopolysaccharides: structural principles and biologic activities.. https://doi.org/10.1093/clinids%2F6.4.428

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