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Gentamicin absorption during prophylactic use for necrotizing enterocolitis.

J C Miranda·M S Schimmel·G M Mimms·W Spinelli·J M Driscoll·L S James·T S Rosen
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Abstract

Gentamicin absorption was measured after oral administration in 18 neonates treated prophylactically in an attempt to decrease the incidence of necrotizing enterocolitis. Patients were given 10 mg/kg/day in four divided doses via nasogastric tube for a total of 10 days. Levels were assayed using the Emit system. Serum levels ranged between 0 and 2.2 micrograms/ml. Mean levels over 10 days were 0.42 +/- (SD) 0.47 micrograms/ml and did not vary significantly from day to day. From these data we conclude that enterally administered gentamicin is not absorbed to a degree that would result in toxic or even therapeutic serum concentrations.

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Birth WeightEnterocolitis, PseudomembranousGentamicinsGestational AgeHumansInfant, NewbornJournal Article

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J C Miranda, M S Schimmel, G M Mimms, W Spinelli, J M Driscoll, L S James, T S Rosen. 1984. Gentamicin absorption during prophylactic use for necrotizing enterocolitis.. https://doi.org/10.1159/000457179

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