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Two non-allelic human interferon alpha genes with identical coding regions.

K Todokoro·D Kioussis·C Weissmann
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Abstract

A hitherto undescribed human interferon-alpha (IFN-alpha) gene, IFN-alpha 13, has been isolated and characterized. Its entire coding sequence is completely identical with that of IFN-alpha 1; the 5' and 3' non-coding regions differ by 4.5% and 3.8%, respectively. As the two genes are not allelic, we conclude that the similarity is due to a very recent gene conversion event. Both genes are expressed in virus-induced leukocytes.

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Base SequenceCloning, MolecularDNA, RecombinantGene ConversionGenesGenetic LinkageHumansInterferon Type ILeukocytesRNA, MessengerTranscription, GeneticJournal ArticleResearch Support, Non-U.S. Gov't

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BibTeXRIS

K Todokoro, D Kioussis, C Weissmann. 1984. Two non-allelic human interferon alpha genes with identical coding regions.. https://doi.org/10.1002/j.1460-2075.1984.tb02050.x

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