Guanyl nucleotides decrease antagonist binding at high affinity dopamine receptors.

A C Andorn; K R Kohagen

doi:10.1016/0014-2999(84)90198-5

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Guanyl nucleotides decrease antagonist binding at high affinity dopamine receptors.

A C Andorn·K R Kohagen

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Abstract

Guanyl nucleotides induce a loss of high affinity [3H]spiroperidol binding sites in rat striatum that can be demonstrated by rate association, equilibrium dissociation and saturation analyses. [3H]Spiroperidol is an antagonist ligand for rat striatal dopamine receptors. These data therefore demonstrate clear cut effects of guanyl nucleotides on antagonist binding.

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Animals Binding, Competitive Corpus Striatum Guanine Nucleotides Guanylyl Imidodiphosphate In Vitro Techniques Kinetics Magnesium Rats Receptors, Dopamine Spiperone Journal Article Research Support, U.S. Gov't, P.H.S.

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A C Andorn, K R Kohagen. 1984-08-03. Guanyl nucleotides decrease antagonist binding at high affinity dopamine receptors.. https://doi.org/10.1016/0014-2999(84)90198-5

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