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PubMed · 6481161

Mitogen-induced human IgG subclass expression.

M G Scott·M H Nahm
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Abstract

To investigate human isotype expression among lymphocyte populations, we have studied IgG subclass production by splenocytes, tonsil cells, and peripheral blood lymphocytes (PBL) after stimulation with a panel of nine mitogens. Response magnitudes varied with tissues: all mitogens produced the strongest responses with splenocytes and the smallest with PBL. In addition, the IgG subclass maximally stimulated by a particular mitogen also depended on the tissue studied. For example, LPS mainly stimulated IgG2 in PBL and IgG1 in spleen. Interestingly, the response patterns seen in splenocytes suggest a large and coordinate expression of IgG1 and IgG3 subclasses. Implications of these findings are discussed with respect to immunoglobulin gene organization and human disease states.

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Antibody SpecificityChildDose-Response Relationship, ImmunologicHumansImmunoglobulin GImmunoglobulin MLymphocyte ActivationLymphocytesMitogensPalatine TonsilSpleenJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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M G Scott, M H Nahm. 1984. Mitogen-induced human IgG subclass expression.. https://pubmed.ncbi.nlm.nih.gov/6481161/

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