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PubMed · 6481812

Radionuclide ventriculography: usefulness in evaluating alterations in ventricular function.

J S Rellas·J Sokolov·J R Corbett·S E Lewis·J T Willerson
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Abstract

Radionuclide ventriculography allows the visualization of the right and left ventricles, the objective quantitation of right and left ventricular function at rest and during stress, and an evaluation of the influence of a variety of different physiologic, pharmacologic, and surgical interventions on global and regional ventricular function. The further development of tomographic imaging devices and sophisticated associated computer systems should allow sensitive three-dimensional analysis of global and segmental ventricular function and evaluations of the interrelationships between myocardial perfusion, metabolism, and function.

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Angina PectorisCardiac OutputCardiac VolumeCoronary DiseaseDiagnosis, DifferentialExercise TestHeart VentriclesHemodynamicsHumansMyocardial ContractionMyocardial InfarctionRadionuclide ImagingTechnetiumJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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J S Rellas, J Sokolov, J R Corbett, S E Lewis, J T Willerson. 1984. Radionuclide ventriculography: usefulness in evaluating alterations in ventricular function.. https://doi.org/10.1016/s0022-2828(84)80654-9

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Effect of a hypoglycemic agent on ischemic preconditioning in patients with type 2 diabetes and stable angina pectoris.

OBJECTIVE: Ischemic preconditioning is an increased tolerance to myocardial ischemia during the second of two consecutive exercise tests. ATP-sensitive K(+) channel blockers, such as glinides and sulfonylurea drugs, can induce loss of ischemic preconditioning. This study aimed to investigate the effects of repaglinide, a hypoglycemic agent with an affinity for myocardial ATP-sensitive K (+)channels, on the results of consecutive exercise tests in patients with diabetes and multivessel coronary artery disease. METHODS: Forty-two patients with type 2 diabetes and chronic stable angina pectoris, and two-vessel or three-vessel disease participated in this study. The patients underwent two consecutive treadmill exercise tests (phase 1). On the day after these exercise tests, 2 mg of oral repaglinide was given to the patients. One week later, two exercise tests were repeated consecutively (phase 2). RESULTS: All patients achieved 1.0-mm ST-segment depression during the four exercise tests (T1, T2, T3, and T4). In phase 2, seven patients improved in time to onset of 1.0-mm ST-segment depression. The worsening of the time to onset of 1.0-mm ST-segment depression in phase 2 demonstrated ischemic preconditioning block in 83.3% of patients (P=0.0001). Even the postexercise electrocardiographic parameters (ST-segment depression morphology and magnitude and arrhythmias) were significantly different between the groups with and without pharmacologic ischemic preconditioning block (P=0.031). CONCLUSIONS: Repaglinide, an oral hypoglycemic agent with ATP-sensitive K(+) channel-blocker activity, eliminated the myocardial ischemic preconditioning in patients with coronary disease and diabetes.

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