Lithocholate detoxification and biliary secretion in the rat.

N R Pattinson; B A Chapman

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PubMed · 6487341

Lithocholate detoxification and biliary secretion in the rat.

N R Pattinson·B A Chapman

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Abstract

To define the efficiency of hepatic detoxification, 14C lithocholate in combination with taurocholate was continuously infused intravenously into rats until steady-state. Quantitation of hepatic radiolabelled bile acid under these conditions showed only 11% of total liver bile acid was unmetabolised, indicating very efficient detoxification of lithocholate, in its most hepatotoxic state. Interestingly we found the rate for each bile acid to reach steady-state differed. To test whether the difference was due to glutathione S-transferase binding, as proposed by Strange et al (8), glutathione S-transferase levels were induced by phenobarbitone treatment. An increase in cytosol glutathione S-transferase levels had no effect on the time it took for each bile acid to reach steady-state.

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Animals Bile Catalysis Cytosol Glutathione Transferase Inactivation, Metabolic Lithocholic Acid Liver Male Phenobarbital Rats Rats, Inbred Strains Taurocholic Acid Journal Article

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N R Pattinson, B A Chapman. 1984. Lithocholate detoxification and biliary secretion in the rat.. https://pubmed.ncbi.nlm.nih.gov/6487341/

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